Its ATPase activity drives dynamic transitions between monomeric and dimeric forms that can be modulated with mutants modifying the ATPase rate to control end joining versus resection activities.
It is known, though, that these mutants modify the cell length, causing shorter and longer cells, respectively [36], [37], [38].
All these mutants modified the POLDIP3 splicing pattern by excluding mainly variant 1 and leaving mainly variant 2, indicating that the RNA-binding activity of Flag-TDP-12xQ/N was not responsible of the induced loss of TDP-43 activity.
Consistent with this, experimental manipulation of mef2ca mutant transcripts modifies the penetrance of the fate switch.
As shown in Table 1, the dbpAB mutant modified with dbpA overexpression was recovered from each heart specimen from all of the 24 mice that had received a dose of 102 or 103 organisms, albeit the five infected mice in the lowest dose group did not produce a positive heart specimen.
This suggests that factors that influence the degree of opening on the cytoplasmic side of the triple mutant may modify the transport kinetics.
We therefore examined the extent to which naturally occurring genetic variation modifies the mutant hINS phenotype in the eye and notum.
Given the chromosomal proximity, it would be hard to make a double mutant of sei and ppk29, but perhaps RNAi could be used to confirm that reducing sei modifies the ppk29 mutant phenotype?
Each of the Sx1A Cys mutants, differently modify the kinetics of Cav1.2, and neuronal Cav2.2 calcium channel.
We predicted that mutation of Nnt in C57BL/6J mice modifies the Bcl2l2 mutant phenotype.
