Sentence examples for mutant models with from inspiring English sources

The energy consumption was then altered so as to produce mutant models with different relative swarming fitness values.

The V71E mutant model with the lowest Rosetta score was selected from those 500 candidates, resulting in a set of 1724 mutant models.

In addition, two mutant models have been established with inactivated tumor suppressor genes.

However, as previous examples have shown, evolutionary mutant models can be combined with established laboratory models for functional and translational studies, e.g. by expressing the gene of interest from the evolutionary model as a transgene in zebrafish and medaka, or by knocking down the zebrafish or medaka homolog (Schartl et al., 2010; Yergeau et al., 2005).

A combined treatment with everolimus and IMO is effective in VHL wild-type and mutant models of RCC by interfering with tumour growth and angiogenesis, thus representing a potentially effective, rationale-based combination to be translated in the clinical setting.

Taken together, our results demonstrated that a combined treatment with IMO and everolimus is effective in VHL wild-type and mutant models of RCC by interfering with both cancer cells and microenvironment.

However, the calculated mutant models just bear tiny variations compared with the corresponding original structures (r. m. s. d. values less than 0.1 Å).

Importantly, the phenotypes of both homozygous mutant models are identical and dramatic: newborns with essentially no epidermis nor epidermal appendages, absence of hind limbs, only rudimentary forelimbs, craniofacial abnormalities, and profound defects in other stratified epithelial tissues (urothelium, mammary and prostate) 2, 3.

Comparison of genome-wide expression data from the mutant mouse models with human tumour material of mutant or wild-type WT1 datasets identified the stage of origin of human WT1-mutant tumours, and emphasizes fundamental differences between the two human tumour groups due to different developmental stages of origin.

Further analysis using compound mutant mice models with either HR or NHEJ deficiency may assist in elucidating the role of cohesins in this context.

We tested this hypothesis by analysing the proteins isolated from sequential extractions of cartilage from mutant mouse models with different genotypes.