Sentence examples for mutant models were from inspiring English sources

Mutant models were subjected to a 1000-step energy-minimization process using the Amber force field parameters in the UCSF Chimera [ 52].

The docking studies of protease inhibitors (atazanavir, darunavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir) with the wild type and mutant models were carried using AutoDock 4.2.5.

The resultant "mutant" models were simulated as before, and as shown in Figure 5 (panel B), the simulations accurately reproduce the experimental data [ 19] (again with the exception of the slight dip in cAMP profile seen in the wild type and pde2Δ model mutants).

Moreover, the size of tumors in lipase mutant models was reduced in comparison to wild type mice, indicating a role of TAG lipolysis not only in cachexia, but also in the development of the tumor itself.

Given the different development stages where nephron development in our mutant models is blocked, we decided to compare the genome-wide expression patterns of the mice to the two main groups of human Wilms' tumour (WT1-mutant and WT1-wild-type).

Importantly, the phenotypes of both homozygous mutant models are identical and dramatic: newborns with essentially no epidermis nor epidermal appendages, absence of hind limbs, only rudimentary forelimbs, craniofacial abnormalities, and profound defects in other stratified epithelial tissues (urothelium, mammary and prostate) 2, 3.

A mutant model is then re-solved to predict a new growth rate optimum.

The GPA2 Q 300 L (Gpa2 constitutively active) mutant was modeled by setting the concentration of GPa to 1 and the parameter V maxGPdeact to 0. The pde2Δ mutant model was simulated as described earlier.

Development of arthritis in the gp130 mutant model is dependent on CD4+ T cells despite the finding that mutation of gp130 in nonhematopoietic cells is sufficient to drive disease.

The orbits of the wt and cwo-mutant models are almost periodic in the sense that each orbit revisits a very small neighborhood of the phase space at the end of each LD cycle (Figures 3b c, 3d, and 3g).

Equations (1) and (2) reveal that the cycle-to-cycle peak-time variability of per and tim in the cwo-mutant model is always larger than the variability of CLK/CYC.