Sentence examples for mutant models expressing from inspiring English sources

I will discuss new data arising from the analysis of mouse mutant models expressing developmental disorders and susceptibility to cancer.

Both in vitro studies of recombinant mutant αB-crystallin and transgenic models expressing the mutant protein in vivo have contributed to our understanding of the effect of this mutation on protein function [27], [31] [33].

Various worm transgenic Tauopathy models expressing mutant human Tau constructs have therefore been generated and yielded complementary findings in regards to the effects of neuronal Tau expression [33 35].

I work in hearing research, and I am now working on genes that are linked to blood (platelet) disorders as well as with mouse models expressing mutant steroid (androgen) receptor genes.

In conclusion, our fly models expressing mutant hHtt and hAtx1 in glial cells or glial lineage stem/progenitor cells have extended the non-cell autonomous pathology hypothesis as well as the developmental effect hypothesis to multiple polyQ diseases.

Mouse models expressing mutant presenilin 1 and APP demonstrated that Aβ peptides are preferentially produced or deposited in autophagic compartments[13], raising the possibility that a physical interaction may occur between Aβ1 42 and autophagic vesicles.

Transgenic mouse models expressing mutant superoxide dismutase 1 (SOD1) have been critical in furthering our understanding of amyotrophic lateral sclerosis (ALS).

Indeed, we show that mammary tumours appear earlier in mouse breast cancer models expressing mutant huntingtin as compared to control mice expressing wild-type huntingtin.

Finally, transgenic models expressing mutant glycoproteins have also proved very useful in deciphering the GQC pathways and their role in the pathophysiology of human disorders.

However, it became increasingly obvious from animal models expressing mutant Tau that Tau pathology appears prominently in the stratum lucidum (s.l). of area CA3 where axons of granule cells form the mossy fiber path [ 7- 9].

Studies on animal models expressing mutant SOD1 have provided evidence that the subsets of neurons that exhibit selective vulnerability in brains are more prone to increased stress associated with protein misfolding at the endoplasmic reticulum (ER).