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Transgene-rescued EPOR null mutant mice when subjected to IRI showed a larger infarct size and reduced left ventricular (LV) function compared with wild-type mice with intact EPOR [29].
MARCKS expression was increased in sdy mutant mice when compared to wild-type mice.
Indeed, the metabonomic analysis of liver tissue shows the same changes in taurine levels as seen in the urine, i.e. taurine levels are reduced in liver tissue of 391 mutant mice when compared to lean wild-type mice (Figure 5BC).
No significant changes in aortic valve and ventricular functions were observed in adult mutant mice when compared with age-matched control (data not shown).
However, calbindin staining of cerebella showed an apparent impairment of the PC dendritic arbor in P0 P8 PT-treated mutant mice, when determined at P15 (Fig. 3G).
It is also important to note whether there was a baseline deficit between the vehicle-treated WT and Fmr1 mutant mice when interpreting the effects of pharmacologic treatment.
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At P13, CD4 and CD8 mature T cells were found to be slightly enriched in frequencies in the spleen of double-mutant mice when compared with WT mice, Rac1N, and Rac3KO littermates (Fig. 4A C), although reduced in total number as a consequence of defective cellularity of the organ at this time (Fig. 1E).
Dodge and coworkers showed a shortening of survival in mutant SOD1 mice when the inhibitor was applied directly to the central nervous system.
There was no difference between mutant and normal mice when it came to investigating an empty cage, however, and the mutants even outperformed normal mice on a test of spatial learning and memory, suggesting that their deficit was specific for social behavior.
When compared to the WT mice, there was a 6.8-fold increase in the Hq mutant mice islets (p<0.05), when islets were exposed to H2O2 (Fig. 2A&B).
We show that these new mutant mice are hyperactive when exposed to a new environment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com