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Rate of weight change per day was affected by genotype (ATP8B1 mutant mice lost more weight than WT), strain (B6 mice lost more weight than 129 and F1 mice), diet (mice lost more weight on cholate diet), and sex (females lost more weight, or gained less, than males); there are also several interactions (Table 1; Figure 2).
The surviving wild type and mutant mice lost ~20% of their body weight by day 3).
The first evidence of the important role of WNT signaling in the ovary was provided by Vainio et al., which demonstrated that WNT4 mutant mice lost most of their oocyte reserve in the days prior to birth [ 24].
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The TRPM1 null mutant mouse completely loses the ON bipolar cell photoresponses to light, indicating that TRPM1 plays a critical role in the synaptic transmission from photoreceptors to ON-bipolar cells [13], [15].
The Tokyo University professor has just unveiled mutant mice that have lost their innate fear of cats.
Their results show that loss of V1 neurons early in development is not compensated for by any reconfiguration of the circuit — the mutant mice that chronically lost V1 neurons at early stages exhibit the same slow locomotor rhythm as that observed when neurons are acutely silenced after the circuit is formed.
In Raldh2 mutant mice, Ipf1/Pdx1 expression is lost in the dorsal but not ventral pancreatic bud and mutant mice present with dorsal but not ventral pancreatic agenesis [17], [18].
In support of a role for Fgf8, salivary gland development is disrupted in conditional Fgf8 mutant mice, where Fgf8 is lost in the oral epithelium (Jaskoll et al., 2004).
Thus, many SP T cells that accumulate in mutant mice did so without losing their coreceptors.
On cholate diet, mutant mice of all strains lose weight (p<0.001 for all comparisons of mice on control versus cholate diet, except p<0.01 for F1 females; Figure 2b).
But in hearts removed from heart-specific clock mutant mice, that oscillation was completely lost.
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