Exact(3)
Strikingly, marked and widespread signs of dysplasia, with nuclear pleomorphisms and initial loss of normal architecture, heralding malignant transformation, were scored in all the mutant mice exposed to ethanol, but not in the control-fed littermates nor in ethanol-fed normal mice.
It will be of interest, following a longer latency, to analyze various irradiated mouse tissues histologically, in order to look for asymptomatic tumors as described for wild-type and p21-tumor suppressor mutant mice exposed to a whole body γ−irradiation [28].
We observed that P2 mutant mice exposed to phototherapy from birth had significantly lower plasma bilirubin levels (3.65±1.17 mg/dl; n=5) as compared with mutant mice not treated with blue light (10.31±0.44 mg/dl; n=3; P≤0.001; Table 1).
Similar(57)
In later gestation, non-retinoic acid exposed Foxc1 mutant mice display severe cerebral hemorrhage whereas retinoic acid treated embryos do not, suggesting that the rescue of neocortical defects may also improve vascular development (J.A.S. and S.J.P., unpublished observations).
WNT7A mutant mice display several Müllerian duct derivative abnormalities.
Pax3 mutant mice display absence of muscular diaphragm.
Mutant mice exhibit mania-like behavior (Roybal et al. 2007) and altered sleep patterns (McClung 2013).
Other mutant mice exhibit parasagittally-restricted ectopias.
Wnt5a heterozygous mutant mice exhibit impaired osteoclastogenesis.
When mutant mice were exposed to PT from P0 to P15, we observed 100% survival of treated mice (Fig. 3B).
Bcl11b control and mutant mice were exposed to the open field test to analyse locomotor (horizontal) activity as well as leaning and rearing (vertical) activity.
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