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Behavioral assessment revealed that mutant mice displayed more anxiety-related responses and reduced social dominance.
Similarly, hippocampal CA1 pyramidal cells in mutant mice displayed normal place-related activity in a full-cue environment but showed a reduction in activity upon partial cue removal.
Taken together, these data suggest that mutant mice displayed both short- and long-term memory deficits.
We therefore attempted to determine whether mutant mice displayed a decline in mental faculties.
Immunohistochemical evaluation of pancreata from Hq mutant mice displayed much smaller islets compared to wild-type mice (WT).
Alkbh1 mutant mice displayed phenotypes of incomplete penetrance, including unilateral eye malformations, neural tube defects, and craniofacial and skeleton associated abnormalities.
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Pax3 mutant mice display absence of muscular diaphragm.
WNT7A mutant mice display several Müllerian duct derivative abnormalities.
(J,K) At P10, outer pillar cells of mutant mice display CD44-positive ectopic lumens at apical junctions.
Outer pillar cells of mutant mice display fragmented F-actin belts (arrows), as revealed in transverse (K,L) and surface planes (M,N).
E2F3 is essential for full viability and E2f3 homozygous and heterozygous mutant mice display a variety of developmental abnormalities that are consistent with a dose-dependent requirement for E2F3 in the induction of proliferation.
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