Sentence examples for mutant mice containing from inspiring English sources

This study aimed to generate mutant mice containing the Acvrl1 gene flanked with LoxP sequences to allow conditional deletion of Acvrl1 by the LoxP/Cre system.

Mouse embryonic fibroblasts (MEFs) derived from dlg mutant mice contained an increased number of multinucleated cells and showed reduced proliferation in culture.

Genotyping PCR demonstrated that eggs from mutant mice contained the Separase mutation (Figure 1D).

Adipose tissue of wild type and ob/ob mutant mice contained less than 5 preadipocyte/macrophage-like cells per 250 adipocytes while Nscl-2 mice showed a 7-fold increase of cells of the preadipocyte/macrophage-like lineage in WAT at 6 months of age (F = 250.71; dF = 3; p<10−4; Fig. 5A).

Based on immunohistochemistry, we determined that sciatic nerves of Dicer mutant mice contained no B-cells (B220) and only rare T-cells (CD3; 1.6±0.6% positive cells per total number of nuclei in Dicerfl/fl Dhh-Cre+ nerves versus 1.6±0.2% in controls, p = 0.96, Fig. 2c).

Lung capillaries in the mutant mice contained numerous granulocytes, but there was considerably less hemorrhage than in the p210 BCR/ABL1 mice.

The brain cells of these mutant mice contained fewer dendritic spines than mice with normal γ-secretases.

Importantly, epidermis and dermis of Bmal1 mutant mice contained mitotic cells, indicating that the proliferation defect was hair follicle specific.

Mutant mice contain an artificial transgene in addition to the additional copies of the specified region of chromosome 16.

As previously described (Wang et al., 2003), prostates in mutant mice contained regions of normal morphology, as well as areas of prostatic intraepithelial neoplasia (PIN) and frank adenocarcinoma.

The Per2-mutant mice contain a point mutation (G-to-T transversion) in the Per2 gene that leads to the generation of PER2 protein containing an 87-amino-acid deletion.