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We proposed that the I149V mutant may play a role in the unique 150-loop properties of 09N1.
In summary, the lpa-causing mutations in 3mlpa mutant may play a role in initiating defense responses during seed development.
Some of the cytochrome P450-encoding genes that are affected in the glu1-2 mayant may play a role in the phase I of this detoxification [ 98].
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A larger cohort is needed to draw significant conclusions about the role that mutant RAS may play in radio-resistance of lesions to radioembolisation.
Animal models of disease have provided some insight into the role that mutant GCAP1 may play in retinal pathology.
This suggests that toxic oligomeric species of mutant HTT may play a critical role in synaptic dysfunction in HD.
Misfolding of mutant enzymes may play an important role in the pathogenesis of cystathionine β-synthase (CBS) deficiency.
We did not observe significant differences in frequency of mutated genes for CRP (G1059C), IL1ra (genotype 2/2), IL-6 (G176CD14CD14 (G-159T), TLR2 (G2259A) and CCR2 (G190A) between the non-healing and healing fractures, although its has been reported that these mutant genes may play role in wound healing and inflammation.
Furthermore, we describe additional modifications to these assays that can be used to screen for additional chromatin assembly mutants or characterize existing mutants that may play a role in chromatin metabolism.
This trichome phenotype suggests that, unlike other constitutive pathogen response mutants, CPR5 may play a more specific role in trichome development.
Depletion of α-KG, an essential citric acid cycle intermediate, in IDH1 mutant tumor cells may play a role during tumor development [ 28] but competitive inhibition by D-2HG of the 60 known α-KG-dependent enzymes appears to be a more important factor [ 29].
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