Sentence examples for mutant may lead from inspiring English sources
In our opinion, this could indicate that according to different proteomic contexts (i.e. HeLa versus KGN), the FOXL2-C134W mayant may lead to slightly different (impaired?) stress responses.
This in turn may be of great clinical importance for the selection of drug-resistance under antiviral treatment because a higher or lower steady state level of a resistant mutant may lead to a faster or slower outgrowth.
Loss of Fur function in the fur mutant may lead to increased toxic levels of intracellular iron that can cause excessive reactive oxygen radical production and DNA damage which is not conducive to L-form formation.
The preceding observations suggest that sustained elevation of presynaptic calcium in the dP32 mutant may lead to reduced neurotransmitter release.
First, insufficiency of the UPR in the ssa1/2 deletion mutant may lead to activation of the ubiquitin-proteasome protein degradation system.
Deregulation of photorespiration in the glu1-2 mayant may lead to a reduced elimination of excess excitation energy, and hence an imbalance in the redox status.
Changes of photosynthetic reactions of mutants may lead to an increase of the carotenoids content, which protect cells against the light stress.
Such mutants may lead to improvement in crystallization, as mutation of one nucleotide often strongly affects resolution [30].
The changes in cell viability were small for PrPCTM or PrPPG14 possibly because the stable selection of these neurotoxic mutants may lead to the elimination of a subpopulation of cells that are more susceptible to the pathological effects of the PrP mutants.
In addition to ensuring proper lysosomal function, ATP13A2 may work in mitochondria, such that the reduced activity of ATP13A2 mutants may lead to mitochondrial defects that contribute to neurodegeneration) [ 43].
As S. aureus attaches and develops an initial biofilm, heterogeneity arising as a result of generation of Agr mutants may lead to a more robust structure with improved adherence properties.
