Rather, the 3D model suggests that MLK3 mutants may interfere with its scaffold properties, and thus are likely to impact MAPkinase signalling.
Ablation of CDH1 expression in mutant LGN may interfere with the sorting of axonal projections leading to the defects seen in the Chrnb2−/− mutant visual system.
Thus, we evaluated whether co-expressing wild-type or mutant TPCs may interfere with LRRK2-mediated autophagosome formation.
Mutant MLE proteins may interfere with formation of the complex, which normally results from the presence of maternal gene products (including the msl2 transcript).
The RAP1 – rif2 60 [F8Y] mutation more closely resembled the RAP1 – rif2 60 [F8A] mutant, suggesting this residue may interfere with function.
First, these mutant versions of Spt16 may interfere with the normal recruitment of FACT to transcribed DNA.
The accumulated PTEN ATP-binding mutants in the nucleus may interfere with PTENWT forming a complex with p300 for p53 acetylation, and therefore reducing both the stability and the transcriptional activity of p53.
The results obtained with the p66Shc mutants suggests that p66Shc may interfere with CXCR4/CXCR5 coupling to Vav by acting as an adaptor to recruit negative regulators of the TK-dependent or the PI3-K-dependent pathways triggered by these receptors.
Additional characterization of a set of our mutants suggests that these mutations may interfere with compensatory growth in different ways and that at least one also curtails tissue overgrowth.
