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Together, these findings suggest that the inappropriate production of the H3.5 mutant may compromise proper chromosomal function in tumor cells.
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Results obtained with constitutively active Raf mutants has been questioned, since the lack of the regulatory domains in the Raf mutants may compromise the substrate specificity and the dynamic regulation of activity [ 9].
In the case of the R394H mutant, co-expression with wild-type TRIM32 reduced the level of dysbindin monoubiquitination potentially indicating that this mutation may compromise the function of the wild-type protein (Fig. 5E).
Inter-study variation may compromise the reliability of these results.
Studies by Leonardi et al. have indicated that mutant IDH may compromise the ability of this enzyme to catalyze the Gln-dependent reductive carboxylation reaction.
Thus, similarly to the acetyl-CoA transporter, more than one process is impaired in sdh1Δ mutants, which may compromise lifespan.
We have identified viral envelope mutants in this study that may compromise HBsAg detection in HBV-infected donors.
Similar observations of the localization of constitutively active myosin-V were recently reported, suggesting that regulation of this mutant may be compromised [ 23].
Our tentative explanation for this is that the assembly rate of LI is sufficiently high to make enough active regulator whereas the LI/II double mutant may be compromised for both assembly and stability, resulting in an intracellular copy number too low for cfa activation.
At later time points, miRNA profiles in mutant retinas are more variable suggesting that miRNA-related mechanisms that may compromise retinal function are activated between these phases of the disease.
This suggests that reducing
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