The high-activity mutant may be therapeutically valuable.
The early-maturity mutant may be important for future space cultivation.
Thus, the mutant may be used to effectively prevent -cocaine from entering brain and producing physiological effects in the enzyme-based treatment of cocaine abuse.
Finally, such a mutant may be employed for improving its desirable characteristics through evolutionary engineering methodologies in order to speed the fixation and breeding of the genetic traits with industrial interest.
To assess the possibility that the impaired chloroplasts in asl3 mutant may be reflected at the level of related gene expression, we examined the transcription levels of genes associated with photosynthesis and chloroplast development both in the asl3 mutant and WT plant by qPCR analysis.
This result suggests that W542L mutant may be improperly folded, and as a result does not leave the ER efficiently.
The eventual dominance of the H275Y mutant may be due to a better balance between the hemagglutinin (HA) and NA activity [25], [26].
Thus, the up-regulation of spoT in the C. jejuni Δppk2 mutant may be a compensatory response to keep ppGpp levels low preventing cells from entering stress response.
Since the H486R mutation is also present in the UBD, it is possible that this mutant may be defective in ubiquitin binding.
In this case, identification of accumulated RNAs in dis3-54 mayant may be crucial for understanding the mechanism of mitotic arrest in dis3-54 mutant.
In this respect the dominant negative effect observed upon overexpression of this mutant may be explained by the prevalent occurrence of Dnmt1 as a dimer [49].
