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It is also possible that any compensatory phosphorylation on the 35A mutant may affect its mobility shift, more so than the compensatory phosphorylation on the PH-A/linker-A mutant.
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Therefore, these cancer mutants may affect their kinase activity.
Malfolding of SI mutants may affect the trafficking or even lead to degradation via the endoplasmic reticulum-associated protein degradation (ERAD) pathway [8].
Alterations in translation in Arabidopsis trdmt1 trmutantsants may affect translational regulation under stress conditions and reduce plant fitness.
Like bmr2, bmr6, and bmr12, these mutants may affect monolignol biosynthesis and may be useful for bioenergy and forage improvement when stacked together or in combination with the three previously described bmr alleles.
This finding suggests a possibility that expression of seipin mutants may affect HCV, at least in vitro, and potentially increase the risk for liver cirrhosis and hepatocellular carcinoma in BSCL2 patients.
The reduced resistance to E. coli and S. enterica of glp-4 mutants suggests that the mutation may affect a germline-independent mechanism involved in the regulation of innate immunity.
Again, this indicates that the Cbx3 hypo / hypo mutation may affect the same silencing pathway that is affected in the Dnmt3L and Miwi2 mutants [ 21, 22].
The much lower expression of these histone constitution-related genes at the meiosis and uninucleate microspore stage of GMS mutant anther may affect the normal chromosome structure and influence the functional gene expression in the GMS mutant anther.
The increased separation between the OH of Y237 and the hydroxyethyl moiety of heme a3 results in a loss of the hydrogen bonding interaction in the G232V mutant, which may affect proton-coupled electron transfer involving the cross-linked tyrosine in the mixed valence mutant and/or disrupt the K proton channel.
Fourth, mutant p53 may affect cellular senescence.
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CEO of Professional Science Editing for Scientists @ prosciediting.com