These results imply that programmed cell death triggered by JAK2 inhibition in the JAK2V617F mutant cell lines involves both the intrinsic and extrinsic pathways.
Experiments using clear cell renal carcinoma cell lines involve only one of each wild type SETD2 versus mutant SETD2.
There are usually many ways the crosses can be arranged, but each mutant line must be involved in at least one cross.
One of the upland indica (aus) rice accession, Nagina 22, has been induced with EMS (ethyl methane sulfonate) mutagen to generate and characterize 22,292 mutant lines through an Indian National initiative involving several research institutes (Mohapatra et al. 2014).
It may be especially useful to screen NILs or mutant lines to seek the physiological processes involved in phenotypic variations [ 32, 33].
Since LRX proteins localize to the cell wall, the identification of numerous changes in cell wall structures of lrx3, lrx4, and lrx5 mutant lines support the assumption that LRX proteins are involved in cell wall development.
XZ performed genetic manipulations, phenotypic determinations, and biochemical analyses involving the Atss2-1 and Atssingleingle mutant lines and the Atss2-1, Atss3-1 double mutant, and helped to draft the manuscript.
Although CR3-mediated phagocytosis, without FMR association, seems to be the main mechanism driving the internalization of ISP-deficient Leishmania, we cannot discount the possibility that additional receptors are involved in the uptake of the mutant lines.
To identify specific peroxidase genes involved in pod shattering, we analyzed pod shatter mutant lines related to DZ lignification.
To determine which SPL geneswere most likely involved in altered carotenoid profiles of sk156 seeds, mutant lines with confirmed T-DNA insertion knockouts for all miR156-target SPL genes (except SPL5 where mutants were unavailable) were obtained (Additional file 2).
