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In the case of BLOC-1, several homozygous mutant lines exist in more than one genetic background.
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Mammalian cell lines have also been crucial in facilitating the successful cloning of many DNA DSB repair genes; yet, very few mutant cell lines exist for non-syndromic clinical radiosensitivity (RS).
The lines have been drawn capriciously, but the lines exist.
Similar lines exist around the neck.
This occurs when such a line was not used in crosses with other mutant lines (if they exist).
Two prominent researchers were surprised that 60 lines existed.
As HAM1 and HAM2 are closely related genes, functional redundancy might exist to prevent the appearance of a mutant phenotype in the homozygous mutant lines.
However, most of our mutant lines are not alleles of chico and do not interact genetically with p60 nor dp110, suggesting that a pathway parallel to dp110 may exist downstream of the insulin receptor during oogenesis.
Jeng et al. (2012) discovered mutant lines that have higher Fe or Zn concentrations in polished seeds by searching among NaN3-induced mutant lines (Oryza sativa cv. IR64).
Such differences between wild type and mutant have been discovered efficiently in recent years by using NGS sequencing of bulked DNA of mutant F2 progeny from crosses between mutant lines and parental lines in several plant and animal systems.
Instead, most groups focus on the characterization of specific mutant lines.
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