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Most mutant larvae exhibited normal head and tail formation, with underdeveloped tail structures, as well as normal dorsoventral patterning, consistent with the dcr-2 results.
In addition, Dvps35 homozygous mutant larvae exhibited other defects such as melanotic tumor formation.
The was mutant larvae exhibited a significant reduction of leukocytes infiltrating the lateral line neuromasts upon copper treatment.
Methoprene-treated black mutant larvae exhibited a growth trajectory similar to that of acetone-treated control larvae but continued to grow to approximately 10.6 g (Fig. 2).
Finally, double psh; gnbp3 mutant larvae exhibited a similar reduction of Drs as psh single mutants following GI infection with live Candida (Fig. 3C).
Additionally, at 5 days post-fertilization (dpf), all mutant larvae exhibited active movements of the pectoral fins, continuous swimming movements and balance problems (Supplementary material, Videos S1 and S2), compared with wild-type siblings that had saccadic eye movements and were mostly stationary (Supplementary material, Videos S3 and S4).
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The metabolic consequences of the loss of Gp93-expression are profound; Gp93 mutant larvae exhibit a starvation-like metabolic phenotype, including suppression of insulin signaling and extensive mobilization of amino acids and triglycerides.
These results are consistent with the observation that Slbp15 mutant larvae exhibit a developmental delay before the onset of lethality.
(2) The second paradigm investigated a possible role of neuroligins and neurexin in associative learning, based on the observation that Drosophila NrxI null mutant larvae exhibit learning deficits [14].
Pex1 mutant larvae exhibit abnormalities that are analogous to those observed in ZS patients.
Here, we show that zebrafish quetschkommode (que) mutant larvae exhibit a progressive locomotor defect that culminates in unusual nose-to-tail compressions and an inability to swim.
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