In contrast, appetitively conditioned DAMB mutant larvae did not perform significantly different from rosy controls (Figure 4D; p = 0.112).
Ago251B, dfmr13 double mutant larvae did indeed display a dfmr1 null-like phenotype with respect to the gross morphology of the NMJ.
However, homozygous Dsnx3 mutant larvae did not exhibit any detectable melanotic tumors (data not shown).
Moreover, despite some enlarged organs, the overall body size of the mutant larvae does not seem to be increased, again suggesting variable requirements for Tuberin in distinct cells and tissues during zebrafish development.
Further, we confirmed that overexpressing both FoxO NK and Usp in the PGs of FoxO null mutant larvae did not alter the age and size at critical weight nor did it alter final body size when compared to overexpressing FoxO NK alone.
Most enz homozygotes do not develop swim bladders, and subsequently fail to survive past early larval stages (Figure 2A, B). enz mutant larvae that do develop swim bladders survive, but are runted compared to wild-type siblings through adulthood.
While third instar larvae expressing Htt93Q exhibit mutant htt containing aggregates (43), Htt128FL larvae do not form mutant htt aggregates (19), suggesting that the observed synaptic dysfunction is independent of insoluble aggregates or visible inclusions.
Because while moth larvae spin cocoons, butterfly larvae do not.
