Sentence examples for mutant kinases including from inspiring English sources

The results revealed lead compounds with activity against clinically important mutant kinases, including ALK, LRRK2, RET, and EGFR, as well as unexpected opportunities for repurposing FDA-approved kinase inhibitors as leads for additional indications.

Strong H3S10P during metaphase can be observed in cells injected with either wild type or mutant Aurora kinases including AurkC-KD (Fig. 2C).

In addition, inhibition of HSP90, a chaperon involved in regulating conformation of many kinases including mutant BRAF and Akt, has been demonstrated to overcome BRAF inhibitor resistance in melanoma cells.

The third PC dimension clearly separates EGFR and all of its mutants from the rest of the kinases, including ALK and MET.

The ability to inhibit multiple kinases, including the imatinib-resistant ABL T315I mutant, may be advantageous in the treatment of newly diagnosed and advanced disease.

c-Jun's activity is regulated by post-translational modifications that are largely controlled by components of mitogen-activated protein kinase (MAPK) family kinases, including c-Jun N-terminal kinase (JNK), extracellular-signal-regulated kinase (ERK) and p38 kinase.

Mitogen-activated protein kinase (MAPK) kinase activates JNK, whereas MAPK kinase activation is mediated by MAPK kinase kinases, including the mixed lineage kinase (MLK) family in neurons.

There are hundreds of human kinases including around 30 tyrosine kinases subdivided into receptor tyrosine kinases and cytoplasmic tyrosine kinases.

The total amount of 317 kinases included 27 disease-relevant mutant variants.

Oncogenic kinases include Janus kinase family (JAK) and Src [ 56].

Allele-specific RNA interference (ASP-RNAi), small chemical inhibitors of the kinase, including LDN-193189, Smad7 or dorsomorphin has been developed to prevent BMP signaling using a mutant ALK in FOP.