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You could easily ague that Ellen Page being a mutant isn't anything new; she's in very good company in her field.
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One possible explanation is that the KD-RON2 mutant is not only defective for RON2 but also for RON4 and RON5, the latter being also crucial for invasion30.
Notably, a S. cerevisiae tkl1 deletion mutant is not able to grow in synthetic complete medium lacking AAAs.
For example, this mutant is not activated by polyphosphates or by other substrates [34].
This TCRα mutant is not targeted to the ER.
V155A pVHL missense mutant is not existed in nature yet.
The reason telomeres are short in a yku70 -R456E mutant is not clear.
First, UNC93B1 is detected within COPII vesicles, but the nonfunctional UNC93B1-H412R mutant is not.
As expected the STAT3-YF point mutant is not tyrosine phosphorylated after IL-6 stimulation.
However, the exact nature of defects in clr3set1 double mutant is not discussed.
A BiP ATPase mutant is not sufficient to protect cells during oxidative stress.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com