Sentence examples for mutant is still from inspiring English sources

However, the mutant is still susceptible to ponatinib and axitinib [42].

Inactivation of pla severely attenuates Y. pestis during bubonic infection [68], [69]; however, a pla mutant is still lethal during intranasal or intravascular infection [70].

Therefore, the DIA1R-S24P mutant is still expected to translocate to the secretory pathway, but the mutation may affect the size of the mature protein, with resulting impact on structure and function.

We anticipated that the ΔsalKR mutant is still able to colonize these organs, is just due to the WT-mediated impairment of host defense against SS2 infection in these tissues.

The lasR mutant is still able to elicit damage (despite attenuated) and causes stunting of seedlings that differs from wild type PA14 (Fig. 1A, Fig. 4, and Fig. 6B), indicating the presence of additional lasR independent factors that by themselves cause this partially impaired and phenotypically different damage (e.g., pervasive staining of many cell types compared to stomatal staining of PA14).

The transactivation domain of p53 interacts with p300, and this interaction is partially disrupted in the p53L22Q/W23S conformational mutation [17], which has been shown to bind weakly to p300, thus it is defective as a gene repressor and in apoptosis induction [26]; but this mutant is still able to downregulate VRK1 [12].

Other heme peroxidases were less active by orders of magnitude; protein engineering has resulted in impressive improvements but even the most active mutant was still at least an order of magnitude less active than CPO.

When the first 19 residues were deleted, the Sec61β mutant was still able to bundle microtubules with the ER (Fig. 1F).

Attenuation from the vit A2 consensus ERE is not necessarily dependent on DNA binding as the TR alpha DNA binding mutant was still able to inhibit E-dependent transactivation.

Therefore, we generated truncated TcdA devoid of the CROPs (TcdA1 1874) and found that this mutant was still cytopathic.

In contrast, the Gap1-152K9,16R mutant was still delivered to the vacuolar lumen in proline-grown cells (Fig. 5C).