Sentence examples for mutant is mediated from inspiring English sources
Thus, it is likely that that the increase in protease production in the imeBΔ mutant is mediated by XprG.
We postulated that the degradation of the Pro3-1 mutant is mediated by a proteasome-dependent QC pathway.
10.7554/eLife.01498.022 Figure 7. Aberrant phenotype of the PLM neuron in the ptrn-1 mutant is mediated partially by the DLK-1 pathway.
We suggest that upregulation of ISA1 and other genes in the GM077 mutant is mediated by the SUSIBA2-like transcription factor.
Interestingly, despite retaining lysine 402, mutation of the SUMOylation consensus site in the 3mutCS mutant reduced SUMOylation of Ago2 more profoundly than mutation of K402 to arginine, strongly suggesting that the residual SUMOylation of the K402R mutant is mediated through recruitment of Ubc9 via the consensus sequence surrounding K402 (Fig. 3B).
Altogether, these data firmly establish that the U-box domain is not essential for Ufd2 regulation of Yap8 levels and further support the hypothesis that arsenic-sensitive phenotype of the ufd2 mutant is mediated via diminished Yap8 activity.
These results suggest that endogenous p53-R273H contact mutant is mediating the survival of breast cancer cells by suppressing the mitochondrial apoptotic pathway.
Most toxic effects of deleterious mutant are mediated by small soluble aggregates intermediates in the fibril assembly process.
Analysis of the lipid peroxidation signature indicated that lipid peroxidation in the triple mutant was mediated by O2 (Fig. 8D).
It is not clear that these effects in the mutant are mediated by cPML as we have not observed any changes in levels of cPML that would account for the observed down regulation of p21 in the Tgif mutant.
A triple phosphomimetic mutant of PEDF, possessing more potent anti-proliferative, anti-migratory and pro-apoptotic effects in endothelial cells, exhibits higher binding affinity to LR, but not to PEDF-R compared with wild-type PEDF, suggesting that enhanced anti-angiogenic properties of the PEDF triple phosphomimetic mutant are mediated through LR [ 126].
