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These data indicate that the gliding apparatus of the T192 mutant is fully functional and suggest that the increased ratio of non-motile cells observed is not caused by defects in the gliding mechanics.

In our experimental system, the Srs2 875Δ902 mutant is fully capable to inhibit the extension of the D-loop by Polδ in the presence of S-PCNA.

Despite being apparently excluded from lipid rafts, the AC8 N-glycosylation-deficient mutant is fully responsive to CCE (Fig. 4 D ).

It needs be noted that Hellal-Levy et al. [ 16] found that the H950A MR mutant is fully active in the presence of aldosterone.

In summary, all binding experiments show that the exosome complex of the state A mutant is fully capable of interacting with the cap proteins.

An N-terminal deletion mutant of Fip1 in which this binding site is disrupted cannot complement the loss of wild-type Fip1, but the mutant is fully functional if it is fused directly to PAP.

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Mice vaccinated with a single dose of the F. tularensis LVSΔguaA or LVSΔguaB mutant were fully protected against subsequent lethal challenge with the LVS parental strain.

In our hands, a sap1 3Δ mutant was significantly attenuated while a sap4 6Δ mutant was fully virulent.

This mutant was fully functional in the oncogenic transformation rescue assay (Figure 2B).

The individual S303A and LZ4m HSF1 mutants promoted human HSF1-dependent yeast growth to a similar extent, though neither the LZ4m nor the S303 mutant were fully derepressed, as the S303A/LZ4m double mutant displayed enhanced human HSF1-dependent yeast growth (Figure 3A).

As reported previously [13], the EDAA Nef mutant was fully active and Δ12-39 Δ12-39anddisplayE4A4ntermedisplayedintermediateG2activityxA Nef mutants whiledefective for this activity.

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