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In addition, residual proteolytic activity expressed by the hapA-deleted mutant is distinct from HAP, as demonstrated by failure of anti-HAP serum to inhibit the activity of this secondary protease on milk agar.
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This revealed that, at the cellular level, the root growth defect in the brassinosteroid mutants is distinct from that in exocyst mutants.
Thus, hema6 mutation is distinct from other Ank1 mutants described previously.
Some offspring of the five inserted OsOPT mutants showed abnormal symptoms which were recorded in the mutant database and the symptoms of the five OsOPT mutants were distinct (Table 1).
Further, the phenotypes of try, cpc and tcl1 single mutants are distinct.
We conclude that cdc13Δ pif1Δ exo1Δ mutants are distinct from type I and type II survivors, as they do not require Pol32, and their telomeres are maintained through a combination of homologous recombination, Ku and telomerase activity.
The overall morphology of ptena −/−ptenb −/− mutant embryos is distinct from wild-type embryos in that the mutants are shorter and particularly the trunk and tail region is wider.
Thus, we concur with others that have suggested that there must be a toxic form of mutant SOD1 that is distinct from larger protein aggregates with these entities initiating disease.
First, prior analysis of Rb1ΔL/ΔL fibroblasts demonstrates that cell size and length of G1 and S phases are similar to wild type cells, indicating that this Rb1 mutant is phenotypically distinct from the increased rate of proliferation found in Rb1−/− cells [28].
Interestingly, PINCH1 mutant embryos presented a hyperplastic common arterial trunk that is distinct from that seen in FAK mutants, suggesting distinct roles in NCC and OFT morphogenesis.
We conclude that NMD inhibits the growth of cdc13-1 mutants by a mechanism that is distinct to the effects of Exo1 and Rad24, which are more similar in effect.
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