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Importantly, the invasion rate of KO-AMA1 increased in continuous culture to reach 20% after 12 months, suggesting that the mutant is capable of moderate adaptation to bypass the deleterious AMA1 inactivation (Fig. 5d).
Nevertheless, the RB-KN mutant is capable of reducing etoposide-induced apoptosis.
Unlike the null allele of Wu that could not generate mutant somatic clones in the wing discs, our mutant is capable to support limited cell proliferation (Figure 7D).
This is consistent with a report by Onishi and colleagues, that a constitutively active STAT5 mutant is capable of inducing IL-3 independent growth [31].
Zusman et al showed that an L. pneumophila relA mutant is capable of wild-type intracellular proliferation in both human macrophage and the protozoan host Acanthamoeba castellanii [15].
Regardless, the large fold difference (centrosome misorientation/spindle misorientation) under previous and current experimental conditions demonstrates that the apc2 mutant is capable of sensing centrosome misorientation and subsequently delaying mitosis.
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In addition, this mutant was capable to convert secondary and cyclic alcohols, at a rate not detected in the other isoforms.
However, the RD mutant was capable of fermenting a mixture of glucose and xylose with stable yields (0.35 g g−1) and productivities (0.52 g L−1 h−1) during the repeated-batch fermentation.
The remaining mutants exhibited a range of replication efficiencies; however, each mutant was capable of replicating in the presence of concentrations of DSB that effectively inhibited wild-type HIV-1.
We concluded that the W242L mutant was capable of forming heteromers with WT subunits.
In addition, bloodstream forms of the mutant were capable of differentiating to the procyclic form without a detectable growth phenotype.
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