Sentence examples for mutant introduced a from inspiring English sources
The R48A/W191F mutant introduced a binding site for N-hydroxyguanidine near the distal heme face and removed the redox active Trp-191 radical site.
Some mutants introduced a small amount of α(1 4) linkages and α(1 2) linkages.
One of the mutants introduced a premature termination codon whereas the other mutation resulted in an amino acid substitution.
Sequencing reverse-transcribed cDNA from mutants and wild-type littermates with oligonucleotide primers for Nrp1 confirmed that a 4 bp insertion in the mutants introduced a premature stop codon at the end of the transmembrane domain and shifted the mRNA reading sequence out of frame, which prevented translation of the cytoplasmic domain (Fig. 1F).
On the contrary, mutation of the second T of the element (T4 in the exon) has no effect on the splicing pattern, whereas mutation of the first T (T3 in the exon) leads to high levels of inclusion only if changed to G. Since the preceding nucleotide in the exon is an A, this mutant introduces an AG just three nucleotides downstream of the natural AG.
Our computational protocol serves to design point mutants introducing a conformational shift in the ground-state ensemble.
The W of a rare mutant introduced in a population with a SA denoted by overbars 2.1 where R is the total resources for reproduction, r is the proportion of R allocated to male function (=SA), m(r) is the male investment per female mate as a function of r and n is the number of mates.
High lethality of mutants introduces an error-threshold in a multiplicative fitness landscape.
Deterministic haplotype dynamics assuming linkage equilibrium at generation t0 also shows that any A-type mutant introduced into the population is damned to eventual loss no matter how many G loci are segregating in the population.
Deterministic haplotype dynamics assuming linkage equilibrium at generation t0 guarantees that any A-type mutant introduced into the population will be damned to eventual loss no matter how many G loci are segregating in the population (see analytical treatment below).
We measured fitness of each secondary mutant introduced into HIVNL4-3, andne and in combination with K103N, using growth competition assays in H9 cells.
