Sentence examples for mutant inhibited the from inspiring English sources

And five, disruption of normal cortactin signaling in muscle cells by expression of the dominant-negative cortactin mutant inhibited the aggregation of AChRs at innervation sites.

It was reported that this mutant inhibited the activity of wildtype Cry1Ab in vivo against M. sexta larvae and in vitro by analyzing pore formation in black lipid bilayers [8].

As an internal control that the p53-inducible GFP indeed detected an elevated p53-mediated transactivation, we found that inhibition of p53 either chemically (with cyclic pifithrin-α) or genetically (by transfection with a dominant-negative p53 mutant) inhibited the production of p53-inducible GFP in response to cisplatin down to the background level (Fig. 1G).

The mutant inhibited the interaction between the fragment and GFP-lamin A, suggesting that the Tudor domain of 53BP1 is required for lamin A interaction (Fig. 2E).

We also excluded the possibility that the M21A mutant inhibited the anaphase APC/C because HeLa cells could still degrade the R42A mutant and Plk1 (supplementary material Fig. S1E).

Moreover, a PrP transgene expressing a mutant PrP with a deletion of the palindrome region acts as a dominant-negative mutant, inhibiting the conversion of wild-type PrPC into PrPSc [ 38].

However, in this case, addition of copper does not produce any protection, suggesting that the copper-free NMBD (CXXC mutant) inhibits the conformational change induced by the copper binding to the TMBS.

In contrast, Y300 in syndecan-1 has been implicated in several signaling roles: it appears necessary for the alignment of syndecan-1 with actin stress fibres [ 66] and a phosphomimetic Y300E mutant inhibits the assembly of lamellipodia and actin-and-fascin bundles by activated syndecan-1 [ 13].

Again, all six mutants inhibited the growth of RCS chondrocytes with Y373C, K650M and K650E-FGFR3 being the strongest inhibitors (Fig. 3C).

In contrast, expression of the JNK1-DN-mutant inhibited the phosphorylation of nSMase1 and c-jun (lane 4; Figure 4a).

Furthermore, deletion of SLA1 in tor1Δ, sch9Δ, and ras2Δ mutants inhibited the actin dynamics and life span.