Recent data in Salmonella suggest CsgC (AgfC) is also involved in the assembly process as a periplasmic factor, with CsgC knockout mutants influencing the structural features of aggregated CsgA (Gibson et al, 2007).
Let us explore how the changes in both the growth potential and division radius of a mutant influence its invasion probability.
Furthermore, daf-12 mutant alleles influence the life span of daf-2 /InsR mutants in an allele-specific manner.
Five substitutions (Q172R, T195L, Q368E, F376Y, K432R) identified from random mutagenesis were added sequentially to the phytase gene of PP-NPep-6A to investigate how the mutant sites influence the properties of phytase.
The absence of CR of the crl1 mutant may influence the nutrient and water status of the plant, and consequently modulate the expression of nutrient and stress related genes.
As the quantifications of amino acid levels and of starvation-responsive genes did not yield conclusive results, we resorted to a genetic experiment to support our notion that the growth properties of PTEN mutant tissue influence the growth of the surrounding and peripheral tissues, and vice versa.
As the temperature-sensitive mutations are not in the known RNA binding region of Snu13p this indicates that these mutants indirectly influence the RNA binding properties of Snu13p.
To test whether NKX2-5 mutants can influence the expression of their off-targets, we cloned the promoter regions of Rad50 and Snai2, which bind to NKX2-5∆HD, NKX2-5Y191C, ELK1, and ELK4, but not to NKX2-5 WT, into a luciferase reporter.
Shuttling-deficient hnRNP A1 mutant influences survival and granulocytic differentiation of normal myeloid precursors as well as proliferation and tumorigenesis of BCR/ABL transformed myeloid progenitors, suggesting that nucleocytoplasmic shuttling activity of hnRNP A1 is essential and important in the regulation of myeloid progenitor cell differentiation and other functions [ 112].
Since we observed a clear colocalization of Cora and Spectrin at the NMJ postsynaptic side (Fig. S3), we looked whether loss of Cora in the dg mutant conditions influenced the synaptic spectrin cytoskeleton.
