In other words, among all cycling cells, the percentage of mutants increases with α, and so does the probability to create 2-hit mutants.
This is due to the fact that the viral load and in consequence the probability to generate new mutants increases with a growing burden of viral strains.
LDH released from macrophages infected with the mutants increased with increasing MOI (Figure 6A) and was always higher than the LDH released following MFN245 infection at the same MOI.
The results showed that optimizing the residue of cleavage site of propeptide will affect the cleavage efficiency of propeptide, and the mature enzyme yield of Leu(P1 Ala mutant increases 50% compared with the wild-type.
We found that polymer yields in a ΔarcA mutant increased significantly with respect to the parental strain.
First of all, we can show by similar methods that the probability of mutant generation increases with quiescence for 3- and higher-degree mutants (Figure 4).
Our results show that the vulnerability of striatal neurons to mutant Htt increases with age.
The MICs of various antimicrobial agents for such mutant strains increases with each additional mutation in the target sites.
Melting temperature (Tm) of R249L mutant increased to 56.8 °C compared with wild type CalB (Tm: 54.5 °C), which was determined by DSF (differential scanning fluorimetry).
They were shown that the growth of all mutants increased gradually with all the concentration of ethanol compare to R-control.
