Sentence examples for mutant in somatic from inspiring English sources

Moreover, the P hspcsp-2B transgenes could rescue the missing cell defect of the csp-3 lf) csp-3 lfn somutantcells 13.

66 B-Raf is oncogenic also in hematological malignancies, and interferon-inducible overexpression of the B-Raf V600E mutant in somatic tissues led to the spontaneous development of non-lymphocytic leukemia.

To further investigate differences between deletion and missense mutations, we compared the fates of homozygous clones of ico mutants in somatic cells of the eye, a tissue that is not essential for viability.

Ionizing radiation has also been used to generate mutants in somatic tissues to study cell lineage, cell autonomy, and lethal mutations.

act-cas9 and all available vasa-cas9 lines can be used with transgenic gRNAs to reveal null mutant phenotypes in somatic tissues.

However, there are no available data so far regarding mutant mtDNA segregation in somatic tissues during embryofetal development in animal models.

If the mutant exhibited defects in somatic or microsporocyte morphology, the fixed spikelets and/or anthers were dehydrated in a graded ethanol series, then infiltrated and embedded into low viscosity Spurr's epoxy resin (Electron Microscopy Sciences #14300).

DNA repair kinetics data from atrad21.1 [ 40], atrad21.3), and other Arabidopsis mutants affecting HR in somatic tissue and with no apparent deleterious defects during meiosis, such as atrad17 [ 26] and gmi1 (a SMC-Hinge Domain containing protein) [ 23], shows that these mutants experience a delay in DNA dsb repair when many DNA dsb are induced.

Combining the smc-5 (ok2421 ) mutation with the GG-NER xpc-1 mutant or the TC-NER csb-1 mutant also enhances UV-induced delay in somatic development compared to the single mutants, indicating that SMC-5 functions in parallel to both branches of the NER pathway in the soma.

These observations prompted us to ask whether positive selection could also be detected in somatic mutants of other cancer-related genes in tumors.

Mutations can increase Cav1.3 calcium current activity through different biophysical mechanisms as exemplified by the two mutants studied here and in somatic gain-of-function mutations characterized in aldosterone-producing adenomas (22,23).