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These corresponded to data sets where the mutant frequency rose rapidly toward fixation (see Figure 3A).
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It follows from the definition that v<1 reflects a decrease in mutant frequency over the period of competition, that is, the mutant is less fit than the wild type, while v>1 reflects an increase in mutant frequency, that is, the mutant is fitter than the wild type.
The mutant frequency was determined using the cII and the lacI mutant analysis systems.
Mognato, M. & Celotti, L. Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation.
(3) The nonlinear nature of the mutant frequency response to UV radiation was noted by several authors in early studies on mutagenesis in bacteria.
Timepoints for determination of lacI mutant frequency were 10, 30, 90, and 180 days of exposure.
DNA alterations secondary to toxicity either did not occur or were of a type not detectable by lacI mutant frequency analysis, such as large deletions.
No increase in lacI mutant frequency in the liver was observed at any dose or timepoint with chloroform, indicating a lack of DNA reactivity.
The ratio of colonies to cells placed on the growth medium is the mutant frequency.
3 lines were chosen for whole genome sequencing based on phenotype: J318 (mutant frequency 8%%), J328 (mutant frequency 4.3%%), and J327 (mutant frequency 2%%).
Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.
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