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The MMS- or UV-induced mutant frequency is quite low for ΔdinB strains carrying any of the plasmid-borne DinB variants.
The relationship between the value of epistasis and the relative mutant frequency is complex and determined by the fitness ranking of individual mutants.
The increased incidence of a second episode within 14, 21 and 28 days of a CQ treatment from 1995 to 1999 correlating with increasing of the 76T Pfcrt mutant frequency is consistent with selection of parasites (be they recrudescence or re-infection) during the post-treatment period.
Mutant frequency is expressed as the ratio of mutant pfu to total pfu.
This increase in mutant frequency is consistent with previous results [ 28].
In lowlands, the mutant frequency is low in dogs and humans, at 4.9% and 8.75%, respectively (Yi et al. 2010).
Similar(46)
The mutant frequency was determined using the cII and the lacI mutant analysis systems.
Thirty days after exposure, the cII mutant frequency was similar in control and exposed rats.
A good correlation of mutant frequency was observed between TaqMAMA and the results of clonal sequencing.
For all studied mutagens, a significant and dose-dependent increase of mutant frequency was observed.
Timepoints for determination of lacI mutant frequency were 10, 30, 90, and 180 days of exposure.
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