Sentence examples for mutant forms contribute from inspiring English sources

Given that the A-type lamins are nearly ubiquitously expressed and participate in so many different cellular processes, it is challenging to explain the cellular and molecular mechanisms by which mutant forms contribute to tissue-specific pathology.

We can also hypothesise that the pro-apoptotic function is due to the action of one of the client proteins either stabilised under these conditions, such as mutant p53, or disengagement from one of its client proteins such as AKT/protein kinase B. Although it is known that HSP90 stabilises mutant p53 forms [ 94], many of these mutant forms contribute to cellular immortalisation and transformation.

Fms-like tyrosine kinase 3 is the tyrosine kinase that is commonly found in an aberrant form, including overexpression and activating mutant forms, to contribute to AML oncogenesis.

Exactly how FET and TDP-43, either the mutant or wild-type form, contribute to these diseases remains unclear.

Our study revealed that the two mutant forms display distinct biochemical properties that could contribute to epileptogenesis by different mechanisms.

We sought to examine whether over-expression of human WT or mutant forms of ASYN impacts lysosomal function and contributes to neuronal toxicity in primary cortical rat cultures.

If the latter, molecular evolutionary theory can suggest how different the functional roles might be by seeking evidence for positive (adaptive) selection for mutant forms of the native proteins better able to contribute to fitness.

The mutant forms of p53 in HC11 cells are thought to contribute to their immortalisation [ 95], but it is not known if, under certain conditions, mutant p53 could contribute to the sensitisation of cells to starvation-induced apoptosis as does wild-type p53 [ 96].

Indeed, it is likely that these aggregates, as well as soluble oligomeric forms of mutant HTT, contribute to disease pathogenesis in a combinatorial fashion.

These mutant forms hark back to Bosch's apocalyptic visions of disorder and self-destruction.

This "influential and controversial" group, reported the writer, "develop mutant forms of urbanism … which accept the megalopolitan condition with enthusiasm".