Cells mutant for the tuberous sclerosis gene Tsc2 also had extra cilia and diluted ciliary protein.
Tu, M.-P., Epstein, D. & Tatar, M. The demography of slow aging in male and female Drosophila mutant for the insulin-receptor substrate homolog chico.
Similarly, Humphrey23 saw the albino tiger salamander as an opportunity to derive a useful new pigment mutant for the axolotl model.
Such regional regulation is particularly evident in plants mutant for the putative receptor TOO MANY MOUTHS (TMM), which produce excess stomata in leaves but no stomata in stems.
In Drosophila, tumorigenic cells mutant for the cell polarity gene scribble (scrib) are actively eliminated from epithelia when surrounded by wild-type cells.
Confirming the importance of these interactions, the affinities of the Erh1D68A mutant for the Mmi195 122 peptide, and the Mmi1R119A mutant for Erh1, were reduced (Supplementary Table 1).
HRM enables the detection of ER22/23EK and N363S genotypes but fails to discriminate homozygous mutant for the BclI polymorphism from wild-type samples, however a simple spike experiment leads to a clear discrimination between these genotypes.
While loss of Dkk1 function is associated with reduction of anterior structures, mice double mutant for the Dkk receptors LRP5 and -6 show a somewhat opposite phenotype, with expansion both of anterior primitive streak derivatives and anterior neurectoderm (Kelly et al., 2004).
Interestingly, embryos mutant for the segment polarity gene porcupine show a similar retention of the wg antigen.
Taken together, our results demonstrate a possible link between WRKY TF and metabolic alteration that supports rad mutant for the cell survival.
Embryos mutant for the Notch ligand Delta-like 1 (Dll1), the primary mediator of Notch signaling RBPjk, or doubly mutant for the receptors Notch1 and Notch2 have randomized laterality.
