Thus, transgenic mice expressing mutant (for example, P301S) human tau in nerve cells show the essential features of tauopathies, including neurodegeneration and abundant filaments made of hyperphosphorylated tau protein6,8.
"Jacob the Mutant," for example, purports to be the reconstruction of a lost text by the real-life Austrian novelist Joseph Roth in which an Eastern European rabbi who flees a pogrom turns into a woman after he arrives in the United States.
In the T14 (BC) mutant, for example, the BC loop of hTIM-1 was replaced with the corresponding region of hTIM-4.
In the case of the E164A/E165A mutant, for example, removal of the pair of charged residues induced a conformational change which decreased the protein's stability under heat stress, altered oligomerization and unfavorably affected the binding of amorphously aggregating proteins.
The monopteros mutant, for example, is expressed in the Arabidopsis embryo, and the mutant is characterized by abnormal divisions in the prospective procambial tissue in the embryo and defective cotyledonary vein formation [10], [11].
(3) Although we expected dRecQ414 allele to be null based on the designed mutations of the translation start codon ATG and the frame shift of the coding sequence, the phenotypes are generally weaker than Wu's null mutant; for example, our mutants die at early pupal stage, but theirs at early larval stage.
My 1989 hardback edition of Beautiful Mutants, for example, gives the reader a hint as to what's coming, featuring a naked figure (male, I think), its head replaced by a seabird, its torso and lower half swathed in jade silk swirled into a mermaid's tail.
In Drosophila imac mutants, for example, synaptic boutons completely disappear from motor neurons due to loss of a kinesin-3 motor that is implicated in transport of active zone cytomatrix proteins as well as synaptic vesicles [45].
Developmental mutants, for example, are frequently transcription factors or signaling molecules.
Finally, a few mutants, for example, N65R, S95R, or T166Y, have their affinities about two to three times lower than that of WT.
Targeted deletion mutants, for example, followed by a challenge might allow determining how important a role this protein plays in virulence.
