Sentence examples for mutant exerts a from inspiring English sources

MS analysis showed that the SVA-SS mutant was phosphorylated on Ser552, whereas this was not the case for the SVE-SS mutant, suggesting that the charged Glu554 in this mutant exerts a negative effect on subsequent phosphorylation of Ser552 by PKA.

This indicates that cortactin W525K mutant exerts a dominant-negative effect, corroborating previous results [ 23].

These data indicate that the GTP-bound Gtr1 mutant exerts a dominant effect on autophagy in the gtr1∆ background.

Studies in hippocampal neurons suggest that the FGF14bF150S mutant exerts a dominant negative mechanism in which the axon initial segment is depleted of NaV channels and NaV current density is reduced (Laezza et al., 2007).

Importantly, the phosphorylation of endogenous MSH2 in the presence of HB-MSH2Y238F wasubstantiallyly (>60%) reduced (lane 7), suggesting that the MSH2Y238F mutant exerts a dominant negative effect on endogenous MSH2 p-Y.

These results are consistent with the conclusion that the NRP1ΔC mutant exerts a dominant-negative effect, possibly via prevention of interactions between the NRP1 cytoplasmic domain and intracellular binding partners important for transducing chemotactic signals and/or sequestration in inactive complexes of PDGF, PDGFR and possibly other cellular components important for chemotactic signalling.

We demonstrated that the ShcY317F mutant exerts an inhibitory effect on TRK-T3 transforming activity.

As expected, this mutant exerted a strong effect on the major:minor axis ratio, whereas wild-type B-Raf had no effect (Fig. 3C).

In contrast, we observed the K151A mutant binds ubiquitinPhospho-Ser65 with 45-fold lower affinity (Kd of ∼7 μM) than wild-type Parkin (middle panel, Fig 3A and B) and the H302A mutant exerted a more dramatic effect with a 265-fold reduced affinity of binding ubiquitinPhospho-Ser65 (Kd of ∼42 μM) (right panel Fig 3A and B).

Moreover, overexpression of the Walker B D2 mutants exerts a dominant-lethal growth phenotype.

For example, while the single CBP or p300 heterozygous mutants exert a milder phenotype than the homozygous mutants, the mice heterozygous for both HATs show phenotypes similar to the homozygous depletion of one or the other paralog [ 22].