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Therefore, it was surprising that app is strongly down-regulated in the sec22 mutant, even though the mutant produces fruiting bodies.
The rfa2 -Δ N x mutant is intriguing, because it does not behave like an rfa2 -A x mutant, even though neither of these Rfa2 proteins is phosphorylatable on their N-terminus.
Here, we show that aggregation of the mRNA granules after stress still occurs in an edc3Δ lsmutantutant, even though the recruitment of mRNA decay factors and formation of P-bodies is precluded.
However, up to ~72 hr of growth, the spectrum and amount of protein secreted into the culture filtrate did not show major defects in the Δ wc-2 mutant, even though gene expression profiles for many secreted hydrolases were reduced.
When we deleted the PH domain from the Gab1, we failed to observe the interaction with the PTP1B-D181A mutant, even though the deleted PH domain of Gab1 is tyrosine phosphorylated.
For example, the vps21 null mutant had higher enzyme activity than the pmt5 null mutant even though the pmt5 null mutant had a shorter doubling time and higher saturation OD600 (Additional file 1).
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Although dwarfed, these can be considered as being distinct from the brassinosteroid (BR) dwarf mutants, even though they are defective in enzymes upstream of BR synthesis.
The ANBR protein cannot rescue the lethality of Roc1a mutants even though it binds all of the Cullins that Roc1a does.
As for normal mice, Reelin treatment was found to induce Dab1 and Akt phosphorylation in all mutants examined, including Pafah1b1+/− Apoer2−/− mutants, even though these animals exhibit cortical layers defects (Fig. 7).
We find that whereas UEV-1 can interact with C. elegans UBC-13, global levels of K63-linked ubiquitination throughout nematodes appear to be unaffected in uev-1 mutants, even though UEV-1 is broadly expressed in most tissues.
However, dietary supplementation with a range of concentrations of C15iso, C17iso, or a combination of both fatty acids did not improve growth rate or fat stores of fat-6;fat-7 double mutants, even though the dietary supplementation successfully increased the levels of C15iso and C17iso in the worms (data not shown).
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