Sentence examples for mutant effects in from inspiring English sources

This large difference between mutant effects in the two isoforms was not anticipated because the AGS mutations are predominantly in the C-terminal domains shared by the two isoforms.

While those models were evaluated with respect to their ability to predict the wild-type replication profile, they should be instrumental in defining the expected differences in the replication profiles upon S phase perturbations, and thereby interpreting mutant effects in a more rigorous manner.

For the P582i/RI experiment, Hsp90 mutant effects were compared in matched sets of sibs from the same vial/maternal environment but carrying a wild-type allele of Hsp90.

These results indicate that klp10A knockdown and mutant effects are more severe in late stage 13 than stage 14 oocyte spindles.

The potential pathways that may mediate drug resistance and cancer mortality were also analyzed to provide insight into the unequal mutant GOF effects in human cancers.

To guarantee that the array vector x could be used similarly in the estimation of each of the single-mutant fitness effects in w, the evaluations presented here were based on the sub-matrices of W and S, constructed by including only those columns in which the query mutant corresponds to one of the array mutants.

Fitness, original double-mutant fitness measurements from a screening approach; Score, custom-designed score provided in the SGA dataset or the median estimate for single-mutant effects with product scoring function in the E-MAP and GIM datasets.

Additionally, the L58F,80F double mutant has growth effects in both species.

Therefore, similarly to previous literatures, PD-associated LRRK2 mutants display differential effects in their abilities in Rip2 phosphorylation.

The cTnI IR mutants exhibited minor effects in single myocyte Ca2+-activated tension assays yet prolonged relaxation and Ca2+ decay.

Of these, ARF3 mutants show pleiotropic effects in flower development [ 48].