Sentence examples for mutant distribution from inspiring English sources
The observed positive epistasis under drug-free conditions has a buffering effect on the mutant distribution and caused an increase of the relative frequency of the highly AZT-resistant 2-point mutant M41L-T251Y over the expected frequency if epistasis would be absent.
The effect of these rare, early mutations in the overall mutant distribution can be seen as a departure from a Poisson process.
But as the distance away from this peak increases, a portion of the mutant distribution may move into the vicinity of one or more other fitness peaks, separated from the original one by a valley of deleterious mutations.
In this method, the mutant distribution is plotted as the log of the fraction of cultures with more than " x" mutants vs. the log of the mutants/tube (x).
On the other hand, the Colorado population had a similar mutation frequency as the passively exposed subpopulation from this study (P = 0.55), but a somewhat different mutant distribution (P = 0.068).
RNA viruses have high mutation rates and so their populations exist as dynamic and complex mutant distributions.
Cells with ncs2Δ, pom152Δ, or nup60Δ showed a significant defect in SPB growth during metaphase arrest compared to wild type cells (p-value <1×10−5 using a Kolmogorov-Smirnov test to compare mutant distributions to wild type in three replicates).
After changing the target structure, populations optimized at high mutation rates give rise to highly diverse, non-adapted populations, which contain in their mutant distributions molecules closer to S2 at g = 0 than populations optimized at lower error rates.
RNA viruses replicate as mutant distributions termed viral quasispecies.
This value for the standard deviation probably slightly overestimates the true variation because the wild type and mutant distributions overlap.
PAQ analysis describes mutant distributions as spheres with size which is proportional to the genetic diversity, which varies as a result of enhanced mutagenesis.
