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Indeed the hrk1Δ hog1Δ double mutant displayed increased susceptibility to both fluconazole and ketoconazole.
Consistently, we observed that NEM316 PilB did not modulate the susceptibility of the piliated original host nor that of L. lactis towards 5 CAMPs including mCRAMP, whereas the NEM316 ΔdltA mutant displayed increased susceptibility towards all tested molecules.
N80Q UbcM2 and, to a lesser extent, the R94Q/L98M mutant displayed increased K48- and K63-linked polyUb chain building capacity compared to that of the wt enzyme.
Interestingly, the stf0 mutant displayed increased intracellular survival in THP-1 cells as demonstrated by a 2.5-fold increase in cfu counts 6 days post infection.
The S. Typhimurium strain, but not its isogenic sdiA mutant, displayed increased in vitro invasion after addition of both N-hexanoyl-DL-homoserine lactone (C6-AHL) and N-octanoyl-DL-homoserine lactone (C8-AHL).
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Similarly, in maize, Mu-insertional lox3-4 mutants displayed increased attractiveness to RKNs, and an increased number of juveniles and eggs were accompanied by elevated levels of JA [ 53].
These mutants displayed increased cytopathology and virus shedding into the extracellular medium.
dmib1 mutants showed defects in wing margin specification, leg segmentation, and vein determination, while dneur mutants displayed increased numbers of neuroblasts and sensory organ precursors [9], [10].
The S270T and K874Stop mutants displayed increased time to channel inactivation and thus led to a gain of function in the TRPC6 cation channel.
At these temperatures, we observed that Df 2L dLRCH mutants displayed increased lethality (Figure 6B), indicating that dLRCH activity contributes to the robustness of the fly when placed in harsh environmental conditions.
Untreated myb96-1 mutants displayed increased resistance to B. cinerea.
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