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Therefore, vps22, vps25 and vps36 mutant discs display neoplastic tumor characteristics.
However, vps36 mutant discs display a very robust neoplastic phenotype, but do not activate the Notch signaling pathway significantly, suggesting that activation of Notch is not required for neoplastic growth in vps36 mutant discs.
On the right: PTEN mutant discs display high levels of P-S6K that strongly drop in starved animals.
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tid/alg3 imaginal discs display tissue growth and architecture defects that share characteristics of both neoplastic and hyperplastic mutants.
This overgrowth is particularly striking for vps25 mutant discs, consistent with previous reports [26], but also vps22 and vps36 mutant discs are significantly larger than normal discs (Fig. 4).
However, the overall levels of D are unchanged in Fbxl7 mutant discs, discs that overexpress Fbxl7, or ft mutant discs as assessed by Western blotting.
However, the pattern of stg expression is very variable from disc to disc, both in wild type and in sal mutant discs (data not shown).
Therefore these wing discs or wings are referred to in the text as mutant discs or wings.
Psc-Su z 2 Psc-Su z 2and discs showed the tumor Pcenotype as previously reported (Classen et al., 2009) but Sce KO mutant discs were morphologically indishowedishable from wild-thee discs (Fig. 5).
On the left: PTEN mutant discs have strongly elevated P-PKB levels.
(B ) Regions of Psc/Su(Z 2 mutant discs have normal polarity.
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