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Similarly, mice that express a cytoplasmically truncated type II receptor, which acts as a dominant-negative mutant, develop a degenerative joint disease resembling human OA [ 8].
Transgenic mice expressing CMT type 1C-linked human SIMPLE mutant develop a late-onset motor and sensory neuropathy associated with abnormal myelin infolding, paranodal defects, and altered nodal organization (Lee et al., 2013).
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Supporting this concern, the AQP1 N76S mutant developed a proton conductance, but mediated a WT water-flux (39).
We showed that organotypic cultures expressing the fs260 mutant developed a thinner stratum corneum thickness and exhibited parakeratosis.
Instead, the gi mutant develops a large rosette of leaves and thus is "gigantic" in size compared to wild type plants before finally flowering.
The Congo red assay on M9-CR agar plates showed that the WT and complement strains developed a bdar morphotype and the ΔtolC mutant developed a pdar morphotype, suggesting that the ΔtolC mutation reduced curli production.
In particular, organotypic cultures grown from cells expressing the fs260 mutant developed a thinner stratum corneum with nuclei often present and an enlarged vital layer when exposed to acetone.
Upon reconstitution with Fe(II), but in the absence of 2OG, both ALKBH4 and the C15A/C17A mutant developed a broad and composite absorption band, extending from 400 nm (λ=404 nm, ϵ≈570 M−1·cm−1) to 600 nm (λ=490 nm, ϵ≈260 M−1·cm−1).
For example, the glp-1 (e2141ts ) mutant develops a gonad with no germ cells at the restrictive temperature of 25° and lives longer than the wild type (WT) (Arantes-Oliveira et al. 2002).
crl1 and arl1 mutants develop a normal radicle but form no crown root primordium, indicating that CRL1/ARL1 is a master gene for crown root primordium formation.
Embryos were sorted based on their phenotype; mutants develop a swollen pericardium and lack fin buds.
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