Sentence examples for mutant demonstrating that from inspiring English sources

These effects were not observed in the SIRT1-HY mutant demonstrating that SIRT1 deacetylase activity is required, and raising the possibility that SIRT1 directly targeted β-catenin for deacetylation.

Importantly, mTORC1 signaling was unresponsive to insulin in cells expressing the TSC2-5A mutant, demonstrating that the additional phosphorylation sites on vertebrate TSC2, not found on Drosophila TSC2, are essential for Akt-mediated activation of mTORC1.

The wild-type and Q766H forms of the enzyme restored viability of the yeast double deletion mutant, demonstrating that the human proteins – even the Q766H mutant in the catalytic domain – were catalytically active in yeast cells.

As shown in Figure 2B, Tim was strongly phosphorylated in the presence of active c-Src but not with a kinase-dead mutant, demonstrating that Tim is a Src substrate.

Reactive oxygen species formed by addition of 1 mM methyl viologen or 1 mM hydrogen peroxide had an equally toxic effect on the hfq mutant, demonstrating that Hfq is important for the ability of LF82 to resist a variety of chemical stress conditions.

IGS1-R was strongly stabilized in the nrd1-102 mutant, demonstrating that it is targeted by the Nrd1 Nab3 pathway.

Physiological characterization of each mutant demonstrated that the growth and metabolites accumulation properties of these mutations exhibited significant change upon pathway engineering.

Surprisingly, analyses of the hydA1-1 and hydA2-1 single mutants, as well as the HYDA1 and HYDA2 rescued hydA1-1 hydemonstrated demonsthated that both hydrogenases are able to catalyze H2 production from either fermentative or photosynthetic pathways.

Studies with the NS2A mutant demonstrated that it was unable to produce a larger form of NS1 (Nsuggestingesthat thet the mutation had been selected to eliminate a ribosomal frame-shift "slippage site" in NS2A.

Non-catalytic Cys286 was identified as the only site of modification, but further mutagenesis studies using the C286Q mutant demonstrated that this site was not responsible for inhibition of EhTrxR by Auranofin.

Enzymatic analysis using bacterial extracts from the WT and the tpx mutant demonstrated that the mutant contains reduced peroxidase activity.