Sentence examples for mutant data suggest from inspiring English sources

Some of our phenotypic variability may stem from inconsistent shRNA knockdown (Mohr and Perrimon, 2012), but the mutant data suggest much of the variability must emerge from the network response to bcd depletion (Fig. 1C).

The combined S site mutant data suggest the existence of a new S511A-dependent CFTR cleavage whose generation is either dependent on the non-availability of the expected wt hydroxy group on S or is induced by a structural change after substitution with alanine (but not the negatively charged aspartate).

Both the our phage display and mutant-binding data suggest that amino acids Q139, P140, and D141, located at the tip of this loop, are critical for antibody binding.

Together with the results of our experiments using the R86C and R25C mutants, this data suggest that the kinase-independent function of AKT might require targeting to specific membranes or membrane subdomains, likely those richest in PI 4,5 P2, to which the mutants show enhanced binding.

Given that mdx mice exhibit similar if not greater levels of muscle degeneration/regeneration than Dysferlin mutant mice, these data suggest that the cholinergic signaling defects in Dysferlin mutant mice are not due to generalized muscle damage or regeneration.

Moreover, although this network is based on the normal proteins, and not the mutant proteins, our data suggest the network can modulate pathogenicity of the proteins associated with human disease in vivo.

Since a reeler-like phenotype is also observed in double Vldlr−/−; Apoer2−/− mutants [9], these data suggest that Lis1 is an important component of the Reelin signaling pathway downstream of VLDLR (Fig. 8).

As the expression of P35 was not capable of blocking JNK activation in scrib mutants (data not shown), the data suggest that blocking cell death in scrib mutants is not enough to fully rescue the mutant phenotype if JNK remains active.

Taken together, these data suggest that mutant mice displayed both short- and long-term memory deficits.

Together the data suggest that mutant VAPB inclusions are a region of increased ERAD activity.

These data suggest that mutant p110α uncouples PI3K signaling from HER2.