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These findings support the conclusion that ASPM mutant could induce deficiency in proliferation of progenitors.
Tumor necrosis factor (TNF) family members including TL1A, TNF-α and the mutant could induce antigen-specific IgG and mucosal IgA responses after intranasal administration in mice with antigen OVA or HA (Kayamuro et al., 2009).
Furthermore, on the nutrient-poor media (EMM-2), SJ chk1- hyp mutant could induce hypha at a higher temperature; 33 °C (Fig. 5a).
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In contrast, none of the three Merlin mutants could induce phosphor-YAP increase.
In the presence of oncogenic RAS, however, the silent-activity mutants could induce MEK and ERK phosphorylation via activation of CRAF (Fig. 1) [ 22].
The increased sensitivity to aphidicolin observed in osrecql4 mutants implied that the increased number of DSBs detected in these mutants could induce delayed cell cycle progression or that DSBs might not have been repaired sufficiently by HR.
These data suggest that Rab7a is able to regulate vimentin assembly and disassembly and that CMT2B-causing Rab7a mutant proteins could induce vimentin disassembly.
Neither the GPS nor KLP mutant of Cdc42EP3 could induce the formation of actin or septin fibers.
This mutant could still induce an acid tolerance response and remained susceptible to DCCD treatment, but its relative acid sensitivity was difficult to assess as a consequence of its slow growth.
Therefore, as could be expected, this deletion mutant could not induce the transcriptional activity of p53.
The Xist A-repeat mutant could also induce histone modifications and other chromatin changes on the X-chromosome.
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