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The A98V mutant could have a similar effect.
Given the aberrant behavior of mitotic spindles in the first three cleavages prior to LR symmetry breaking (Bergmann et al., 2003), the it143 mutant could have slightly misplaced neighbors that could as well result in impaired LR symmetry breaking.
Therefore, although the FQ sensitivity of this strain is unknown, a first-step mutant could have been selected in vivo as our patient was treated with levofloxacin for 2 weeks.
This study, however, used the MDA-MB-231 breast cancer cell line, which is known to be RAS mutant and ER-negative, so it is conceivable that the helical domain mutant could have synergized with these features.
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We investigated the possibility that the increased insulin secretion in misc-1 mutants could have an effect on germline proliferation.
However, it is possible that homologously expressed IDH mutants could have limited interaction with endogenous IDH in cells.
One hypothesis was that gcr2 mutants could have weak ABA phenotypes because GCR2 functions redundantly with GCL1 and GCL2 in ABA signalling.
However, the detection of such mutants could have been obscured by an overlapping function on the RT required for RC DNA synthesis.
The protein mutants could have adsorbed with different orientations or with different degrees of denaturation.
Therefore, KTA048 mutants could have glaucoma, although it is very difficult to measure ocular pressure in these mutant mice due to nearly closed eye lids.
Since LHC antenna proteins have a central role in photoprotection, their depletion in the TAM mutants could have reduced the photochemical yield and increased photoinhibition.
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