This mutant could be a potential candidate for the upscale production of S-DMAA.
From the viewpoint of metabolic engineering, the highly accumulated glycogen granules in the ΔcyabrB2 mutant could be a valuable source for the production of biofuels.
This mutant could be used to trap reaction intermediates, through crystallographic methods, facilitating the design of potent inhibitors via structure-based drug design.
However, since DNA ligase is also required for certain types of DNA repair as well as for DNA replication, we wondered if the discontinuous synthesis seen in a ligase mutant could be an artifact of DNA repair.
We propose that this dimer stable eNOS mutant could be utilized in the treatment of diseases in which there is eNOS dysfunction due to high levels of oxidative stress.
The equivalent BTG2 W103A mutant was also unstable, but a G64A-W103A double mutant could be expressed (Yang et al., 2008).
The slow growth of this dynein null mutant could be completely reverted to wild-type-like growth in the presence of benomyl, which can be explained by the observed redistribution of nuclei in the hyphal network.
All together, we can hypothesize that the altered transcriptome in the rad mutant could be due to a group of candidate transcriptional activators and repressors that may play critical roles under such energy crisis conditions.
The S. cerevisiae mutant could be functionally complemented with a plant β-CA from Medicago sativa [14].
The reduction in LcrV expression in the ppGpp null mutant could be responsible for the decrease in IL-10 production.
Indeed, the SmpB conditional mutant could be rescued if plated in the presence of the inducer IPTG (until 24 h growth, data not shown).
