Sentence examples for mutant context in from inspiring English sources

In this study we have addressed the relative importance of the RAS-effectors, RAF and PI3K, in a RAS mutant context in human tumor lines both in vivo and in vitro using a regulatable RNA interference system.

Similar XP reactivation or reversal of I-XCI had already been observed in vivo in mutant contexts in which Xist regulation had been impaired [ 26, 35].

The authors suggest that this "immobilization of the mobile pool" is correlated to these receptors participating in synaptic transmission in the mutant context but a mechanism to explain this is not offered.

Hence, EBNA1 binds DS with a similar efficiency in both the wild-type and in the mutant context.

The Gap1K9,16R mutant was still down-regulated in this mutant context and only a Gap1 mutant with all nine lysines present in NT replaced with arginine turned out to be protected against degradation and stabilized at the plasma membrane [5].

In this mutant context, either neuronal or glial-specific overexpression of lipases can decrease lipid droplets and ameliorate photoreceptor degeneration.

Expression of NvHoxB or NvHoxE in this mutant context leads to a complete or strong rescue of this phenotype, respectively.

In the rep mutant context, the recJ exoI double mutant did show a modest (50%) increase in the frequency of deletions.

It is interesting to note that several studies also suggest the relevance of combined inhibition of CRAF and BRAF in a BRAF mutant context for efficacy and may prove to be relevant strategy for treatment of both NRAS and BRAF mutant melanomas [34], [35].

Our results indicated that in a BRAF mutant context, the reactivation of LKB1-AMPK-mTOR pathway under low energy conditions together with the inhibition of oncogenic BRAF signaling for short periods of time, promoted a pronounced apoptosis response through the de-phosphorylation of Bad, stabilization of BimEL and the down-regulation of Mcl-1.

Since imd regulates Rel but does not interact genetically with loj, Rel signaling in this p24 mutant context could be mediated by the Ire-1/Traf2 pathway rather than via Imd.