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This result is consistent with previous studies showing that many autophagy mutants display reduced mating, but if mutant cells succeed in mating they are capable of sporulation (Kohda et al. 2007; Sun et al. 2013).
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Eighty percent of intravenously implanted carcinoma cells succeed in extravasation.
While the process is fortuitously inefficient, when cells succeed there are few effective treatment options.
We attempted to measure the effect of these mutants on chromatin disassembly in yeast at the PHO5 promoter [ 36], but the mutant cells were too sick to succeed with this assay.
While the authors were able to reproduce some phenotypic features of the disease, including altered regulation of intracellular Ca2+, decreased contractility and impaired sarcomeric organization, they also succeeded to improve the function of the mutant cells with overexpression of sarcoplasmic reticulum Ca2+ adenosine triphosphate (SERCA2a), a major actor of the intracellular calcium handling.
MapZ localization in wild-type and pmp23 mutant cells.
You can say there is a statistically significant effect for your chemical reducing the firing rate in the mutant cells.
In other words, a culture with a million healthy cells and one p53 mutant cell, said Eggan, could quickly become a culture of only mutant cells.
Behavior of the mutant cells provides genetic evidence for several roles of ICRAC in T cells.
In subsequent experiments, the Harvard scientists found that p53 mutant cells outperformed and outcompeted non-mutant cells in the lab dish.
Little to no SMARCA2 is expressed in mESCs, either in wild-type or mutant cells.
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